Antihistamine Cream - 25g (Brand may Vary)

Based on 13 reviews
In stock
Laura Henderson - Medical Content Writer
Laura Henderson
James O'Loan - CEO & Superintendent Pharmacist
James O'Loan
CEO & Superintendent Pharmacist
How we ensure accuracy in our content

What is Antihistamine Cream?

Antihistamine Cream is a soothing treatment for reactions that your skin can experience when you have an allergy or get an insect bite or sting. It helps to reduce inflammation in your skin, perfect for easing rashes, itching, and other symptoms of allergic reaction. This cream can be used by anyone over the age of 6, making this perfect for anyone who suffers with allergies and needs a reliable way to soothe their symptoms.


How will this cream help to soothe allergic reactions in my skin?

This antihistamine cream contains an ingredient called diphenhydramine hydrochloride, an antihistamine which can help to soothe reactions in your skin. It reduces the response that your skin has to allergens, reducing inflammation, itching, and other reactions that your skin can have due to allergies, stings, or bites.


What happens when you have an allergy?

When you have an allergy, your body creates a natural substance called histamine when you come into contact with whatever it is that you’re allergic to. Histamine tells different parts of your body to try and clear the thing you’re allergic to out of your system, which causes symptoms of an allergic reaction, including:

  • Skin rashes
  • Itching
  • Coughs
  • Sneezing
  • Watery eyes


Can I use this cream if I’m taking other medication?

This product is not currently known to interact with any other medications, but you should speak to your doctor or Chemist 4 U pharmacist before using this product if you are taking any other medication. Do not use this cream if you are using any other products that contain diphenhydramine.


Can I use this product if I’m pregnant or breastfeeding?

Antihistamine cream is safe to use during pregnancy and breastfeeding, but you should speak to your doctor or Chemist 4 U pharmacist before using any new medication at this time.


How to use antihistamine cream

Apply antihistamine cream sparingly to the affected area. Do not apply more than twice a day and do not use for more than 3 days without consulting your doctor. Wash your hands after you’ve applied this product, unless they are being treated.


When should this product not be used?

Antihistamine cream should not be used in children under the age of 6. Do not use this product if you are allergic to diphenhydramine hydrochloride or any of the other listed ingredients. For external use only, avoid contact with eyes, nose, mouth, or other sensitive areas. Do not apply to eczema or areas of skin that are broken or producing any form of discharge.


Why do I need to answer questions before I can buy this product?

You do not need a prescription for antihistamine cream, however, you will be asked to complete a short medical questionnaire by your Chemist 4 U pharmacist before we can take your order. This includes some simple questions that all pharmacies legally are required to ask before supplying this kind of product. This helps our pharmacy team to be sure that this product is the best choice for you.


Does this cream have any side effects?

Like all medications, antihistamine cream can have side effects, although not everyone will experience them. These side effects include:

  • Allergic reaction, e.g. skin rash, swelling
  • Skin may become sensitive to sunlight
  • Very occasionally, eczema

If you experience these or any other side effects while using this product, stop use and speak to your doctor or Chemist 4 U pharmacist right away. For more information about reporting the side effects of medication, please see the MHRA’s Yellow Card Scheme.


How to store this product

Store in a cool, dry place which is below 25 degrees C. Do not use if expiry date printed on original packaging has passed. Keep out of sight and reach of children, preferably locked in a cupboard.


Important Information

This product is a medicine; make sure to speak to your doctor or Chemist 4 U pharmacist before taking this product if you have an underlying medical problem or are taking any other medicine or complementary therapy. If your symptoms get worse or continue after taking this product, contact us or your doctor. For medical services in your area, please refer to

If you are pregnant, trying to become pregnant, or breastfeeding, speak to your doctor or our pharmacist before taking this product. If you suffer from any allergies, ask your doctor or our pharmacist if this medicine is right for you.

Store all medicines out of sight and reach of children.

Please read the included leaflet carefully before using this product.

Please contact your GP if appropriate regarding this product.


Helpful Advice on Medication Restrictions & Addiction

For further information on our medication restrictions policy, please click here.

If you are concerned about addiction to 'over the counter' medication, we urge you to visit the below links for professional help and advice:


  • The active ingredient is diphenhydramine hydrochloride 2.0% w/w.

    Antihistamine Cream also contains the following non-active ingredients: propyl hydroxybenzoate, liquid paraffin, emulsifying wax and purified water.

Drug Data
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Does antihistamine cream have Piriton in it?

This product contains diphenhydramine.

This is not the same active ingredient as Piriton which contains chlorphenamine.

I have an itchy rash which appears on my lower legs. I was prescribed a cream by my doctor which clears it, but few weeks later it comes back. Can you suggest a cream to use when it does?

I would recommend trying a mild steroid cream such as Hydrocortisone Cream to see if that eases the rash.

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Shipping Times

MethodHandling TimeTransit TimeTimescaleApprox Cost
Standard Shipping (3-5 Working Days)123£2.95

Times are given in working days and are approximate. Costs may change based on order total, day of the week or location within the UK. Ability to hit timescales will depend on whether the products are ordered before a cut off time, as well as additional administration time incurred in reviewing your order.

Please review the estimates at the checkout.

Shipping Costs

Free UK Delivery on all orders over £30* - Delivery within 3-5 working days.

Standard UK Delivery - £2.95* - Delivery within 3-5 working days.

Express UK Delivery - £4.95** - Delivery within 1-2 working days.

Temperature Controlled Delivery - £8.85 - Delivery within 1-3 working days.

Please Note: These prices are shown as a guide only. All delivery times are approximate but have been obtained in good faith.

*Excluding refrigerated products and treatments which are subject to different postage charges.


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All our items are sent completely discreet for your peace of mind.

This means the packaging is plain, there is no mention of what product is inside your package and there is no mention of Chemist4U either.

We respect that many of our products are of a sensitive nature - this is why we take every step to keep your purchases private.

Returns Information

Customers can read our full returns policy by clicking here

Antihistamine Cream - 25g (Brand may Vary) Reviews

Mrs Fathers,
Seems ok but only used once se rar
Not actually tried this product more than once but seems okay so far
J Richards,
Very good reliable product, always have a tube ready for the summer insect bites and nettles.
Effective for swelling. Shame not one you can use for longer than 3 days.
Excellent product and highly recommend for heat rash and allergic hives on the skin.