Ryaltris Nasal Spray

What is Ryaltris nasal spray?

Ryaltris is a dual-action, prescription-only nasal spray that treats year-round allergy and hay fever symptoms, like a runny, itchy, or blocked nose. It contains mometasone furoate, a corticosteroid that calms inflammation, and olopatadine, an antihistamine that blocks the effects of histamine.

Simply complete a quick online consultation and our expert clinicians will determine if Ryaltris is the right choice for you.

What is Ryaltris nasal spray used for?

Ryaltris treats the symptoms of moderate-to-severe allergic rhinitis in adults and children aged 12 and over. However, we’re unable to prescribe to those younger than 18 from our clinic.

That covers both:

• Seasonal allergic rhinitis (hay fever), triggered by pollen from trees, grass, and weeds, as well as mould and fungal spores.
• Perennial rhinitis, which happens all year round and can be set off by house dust mites, animal hair or dander, feathers, and certain foods.

It helps with a runny nose, sneezing, and an itchy or blocked nose.

How does Ryaltris work?

Ryaltris contains two active ingredients that tackle your allergy symptoms from different angles.

Olopatadine is an antihistamine, so it blocks the effects of histamine, one of the chemicals your body releases during an allergic reaction. That's what settles the sneezing, itching, and runny nose.

Mometasone furoate is a corticosteroid, which reduces the inflammation in your nasal passages that causes a blocked nose, helping you to breathe better.

How long does it take for Ryaltris to work?

Ryaltris starts working in just 15 minutes. After your first dose, your symptoms should start to improve over the first week and stay improved for two weeks, based on taking the recommended two doses a day, as prescribed.

So, while you may feel some relief soon after your first spray, you'll get the most benefit by using it regularly, morning and evening, rather than only when symptoms flare.

How to use Ryaltris nasal spray

Always use Ryaltris exactly as your doctor or pharmacist has told you.

Priming the spray

Before you use the spray, you first need to prime it. To do this, shake the bottle for at least 10 seconds, then take off the purple dust cap.

If it's your first time using it:

• hold the bottle upright
• point it away from you
• press down and release the pump six times until a fine mist appears

If you haven't used it for 14 days or more, shake it well and re-prime with two sprays, or until you see a fine mist.

Using the spray

Use two sprays in each nostril in the morning and evening. Shake the bottle for at least 10 seconds before each use and gently blow your nose to clear your nostrils.

To use Ryaltris:

• Hold the bottle with your index and middle fingers on the finger rests and your thumb under the base.
• Close one nostril with a finger and insert the spray tip into the other, pointing it slightly towards the outside of your nose.
• Tilt your head forward slightly, press down once quickly and firmly, and breathe in gently through your nose as you spray.
• Breathe out through your mouth.
• Repeat for a second spray in the same nostril, then do two sprays in the other nostril.
• Wipe the nozzle with a clean, dry tissue, and click the purple cap back on.

If the nozzle blocks

If the nozzle is blocked:

• pull the spray nozzle unit off
• remove the purple cap
• soak the nozzle unit in warm water for 15 minutes

Afterwards:

• rinse it
• let it dry fully
• put it back together again
• re-prime with two sprays

Never poke a pin or anything sharp into the nozzle, as this could damage it and you won't get the right dose.

If you forget a dose

If you forget a dose, use Ryaltris as soon as you remember, then take your next dose at the usual time. Don't double up.

Ryaltris nasal spray side effects

Like all medicines, Ryaltris can cause side effects, though not everyone gets them.

Common (up to one in 10 people) side effects may include:

• a bitter taste in your mouth
• nosebleeds
• slight irritation inside the nose

Uncommon (up to one in 100 people) side effects may include:

• dizziness
• headaches
• sleepiness
• nasal dryness
• dry mouth
• stomach pain
• nausea (feeling sick)
• fatigue

For more information on Ryaltris side effects, including rare side effects, please refer to the patient information leaflet.

When to seek medical help

Stop using Ryaltris and get immediate medical help if you have signs of a severe allergic reaction, like:

• a swollen face, tongue, or throat
• trouble swallowing
• hives
• wheezing or trouble breathing

Speak to your doctor if you notice blurred vision or other changes to your sight, or if you have ongoing irritation in your nose or throat.

Ryaltris withdrawal symptoms

Ryaltris doesn't cause withdrawal symptoms, and you don't need to wean off it.

Unlike some decongestant sprays, steroid and antihistamine sprays don't cause dependency or rebound congestion, so they're safe for longer-term or daily use.

If your sneezing, itching, or stuffiness comes back after you stop, that's your allergy returning, not a reaction to stopping the spray. It's why you shouldn't stop treatment just because you feel better, unless your prescriber says so.

However, you should contact your doctor if you notice signs your body is absorbing too much steroid, like:

• weight loss
• fatigue
• muscle weakness
• low blood sugar
• salt cravings
• joint pain
• depression
• darkening of the skin

It’s important to note that this is much more likely with steroids taken by mouth than with a nasal spray like Ryaltris.

When not to use Ryaltris

Don't use Ryaltris if:

• you're allergic to mometasone furoate, olopatadine, or any of the other listed ingredients
• you have an untreated infection in your nose, like herpes, as the spray can make it worse
• you've recently had an operation on your nose or injured it

Talk to your doctor or pharmacist first if you:

• have or have ever had tuberculosis
• have any other infection
• are taking other steroid medicines by mouth or injection

Tell your prescriber if you're pregnant, breastfeeding, or planning a pregnancy. Ryaltris shouldn't be used in pregnancy unless your doctor thinks it's appropriate.

Ryaltris can sometimes cause dizziness, fatigue, and sleepiness. If that happens, don't drive or use machinery. Alcohol can make these effects stronger, too.

Some medicines can increase the effects of Ryaltris, including the HIV medicines ritonavir and cobicistat. Always tell your prescriber if you’re taking/using any other medicines.

Storage information

• Keep it out of the sight and reach of children.
• Don't freeze it.
• Use the bottle within two months of first opening it.
• Don't use it after the expiry date printed on the bottle and carton.
• Keep the purple dust cap on the nozzle whenever you're not using it.

Alternatives to Ryaltris nasal spray

If Ryaltris isn't right for you, there are other prescription nasal sprays available for allergies, like:

Dymista: Combines the antihistamine azelastine with the steroid fluticasone propionate for moderate-to-severe allergic rhinitis.

• Generic or unbranded Dymista: Azelastine & fluticasone nasal spray contains the same active ingredients as Dymista and works in the same way but may be available at a lower cost.
• Other dual-action nasal sprays: Dymista Control is another version of Dymista that you can buy over-the-counter without a prescription.
• Steroid nasal sprays: Sprays like fluticasone or mometasone help to reduce inflammation and congestion inside the nose. Examples include fluticasone propionate and its branded equivalents, Flixonase and Pirinase, and fluticasone furoate and its branded equivalent Avamys.
• Antihistamine nasal sprays: Rhinolast contains azelastine and provides fast-acting relief against allergy symptoms.
• Oral antihistamines: Tablets like cetirizine (Benadryl Allergy), loratadine (Clarityn), or fexofenadine (Allevia, Histallay, Treathay) are popular and convenient options, and they're unlikely to make you feel drowsy.

Read our guide to find out the best antihistamine for every symptom.

Avamys vs Ryaltris

Both Avamys and Ryaltris are prescription-only nasal sprays for allergies, but they work slightly differently. Here’s how they compare.

Dymista vs Ryaltris

While Dymista and Ryaltris are similar, they do contain different active ingredients. We’ve put them side by side below to help you decide which one might suit you best.

Frequently asked questions about Ryaltris nasal spray

Can I use Ryaltris long-term?

Yes, Ryaltris can be used long-term, but if you’re using Ryaltris over several months or longer, then it’s advised that you have your nasal passages examined periodically by your doctor.

Can Ryaltris cause headaches?

Ryaltris can cause headaches in some people, but they’re an uncommon side effect. Migraines are also possible, but they’re rare. If you’re worried about any Ryaltris side effects, always speak to your prescriber for advice.

Can Ryaltris cause nosebleeds?

Yes. Nosebleeds are a common side effect. In fact, they're a fairly typical side effect of steroid nasal sprays in general. Aiming the spray slightly towards the outside of your nose, rather than at the middle, can help to reduce irritation.

Can I buy Ryaltris nasal spray over the counter?

No. Ryaltris is a prescription-only medicine in the UK, so you'll need a prescription from a doctor or prescriber before you can get it.

If you're not sure whether it's suitable for you, an online consultation with one of our expert clinicians can help work out whether Ryaltris or another allergy treatment is the better fit.

Sources

• Ryaltris Nasal Spray Patient Information Leaflet. Electronic Medicines Compendium (eMC). [Accessed 3rd September 2026].
• Rapid and Sustained Relief with Ryaltris. Ryaltris. [Accessed 3rd September 2026].
• Avamys Nasal Spray Patient Information Leaflet. Electronic Medicines Compendium (eMC). [Accessed 3rd September 2026].
• Nasonex Nasal Spray Patient Information Leaflet. Electronic Medicines Compendium (eMC). [Accessed 3rd September 2026].