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Promethazine Hydrochloride 25mg - 56 Tablets

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Olivia Malone - Medical Content Writer
Olivia Malone
Medical Content Writer
17/05/2024
16/05/2026
James O'Loan - CEO & Prescribing Pharmacist
James O'Loan
CEO & Prescribing Pharmacist
2084549

Buy Promethazine Hydrochloride 25mg 

Promethazine Hydrochloride 25mg treats short-term insomnia and allergic reactions such as hay fever and rashes. It can also prevent nausea and vomiting.

 

How Promethazine Hydrochloride 25mg works

Promethazine Hydrochloride 25mg belongs to a group of medicines called phenothiazines. It works by blocking your body's histamine, a natural substance that your body makes during an allergic reaction. 

It is a drowsy antihistamine.

 

Directions

Always use Promethazine Hydrochloride 25mg exactly as described in the patient information leaflet or as your doctor / Chemist4U pharmacist has told you. 

Swallow the tablets whole with water.

 

For allergies:


Adults: Start by taking 1 tablet at night. If necessary, increase the dose to 2 tablets a day.

Children (6-10 years old): 1 tablet should be given at night. Do not give children more than 1 tablet a day.

 

Prevention of nausea and vomiting due to travel sickness:

 

Adults: Take 1 tablet the night before a journey. If necessary, take another dose 6-8 hours after the first.

 

Side effects

Like all medicines, Promethazine Hydrochloride 25mg may cause side effects in some people, but these won’t affect everybody. Common side effects include: 

 

  • Dry mouth
  • Blurred vision 
  • Constipation
  • Difficulty passing urine, especially in the elderly or children
  • Feeling drowsy, sleepy or dizzy
  • Headaches
  • Loss of appetite 
  • Sickness and vomiting 
  • Indigestion 
  • Increased sensitivity to the sun 
  • Skin rashes, including itching and red and raised lumps

 

For more information on potential side effects, refer to the patient information leaflet. If you experience any side effects, including any not included in the patient information leaflet, you can report them using the MHRA Yellow Card Scheme.

 

Serious side effects

Seek emergency medical attention if you notice any signs of a severe allergic reaction, symptoms of which include swelling of the face and throat, skin rash, breathing difficulties and/or loss of consciousness. 

If you notice any of the following side effects, stop taking this medication immediately and contact your healthcare provider:

 

  • Yellowing of the skin or whites of the eyes
  • Muscle stiffness or shaking
  • Loss of control in the muscles in your face or head
  • Unusual movements of the tongue, facial muscle spasms, rolling eyes or trembling 
  • Over-active behaviour in children

 

Warnings

Promethazine Hydrochloride may be unsuitable for certain people. Do not take these tablets if you are allergic to any of the ingredients or if:

 

  • You suffer from dizziness
  • You suffer from drowsiness
  • You suffer from headaches

 

Talk to your doctor or Chemist4U pharmacist before taking this medicine if: 

 

  • You have asthma or bronchitis 
  • You have epilepsy
  • You have serious heart problems 
  • You have liver or kidney problems
  • You have a stomach blockage
  • You have difficulty passing urine
  • You have hearing problems 
  • You have narrow-angle glaucoma 
  • You have Reye syndrome 

 

This medication may interfere with test results such as pregnancy tests by urine samples or skin tests. Do not take this medication 3 days before a skin test.

 

Using/taking other medicines

If you are taking or have recently taken medication, including medication obtained without a prescription, talk to your GP or pharmacist before taking this product.

Do not take promethazine hydrochloride if you have taken monoamine oxidase inhibitors (MAOIs) to treat depression in the last two weeks.

Tell your healthcare provider if you are taking the following medication:

 

  • Tricyclic antidepressants e.g. amitriptyline or dosulepin
  • Medicines to help you sleep or feel more relaxed e.g. diazepam or zolpidem 
  • Pain relievers e.g. aspirin 
  • Anticholinergic medicines used for irritable bowel syndrome (IBS), asthma or a weak bladder 

 

Age restrictions 

Promethazine hydrochloride is not suitable for children under 2 years old.

 

Pregnancy and breastfeeding

This medication should not be taken 2 weeks before you are due to give birth. Do not take this product if you are breastfeeding. If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, you must ask your doctor or Chemist4U pharmacist for advice before taking any new medicine. 

 

Alcohol

Do not drink alcohol whilst you are taking this medication.

 

Driving and operating machinery 

This medication can make you feel dizzy. Do not drive or operate machinery until you feel safe enough to do so.

 

Storage information

Store below 25°C in a cool, dry place, away from light and out of sight and reach of children. Do not use after the expiry date, referring to the last day of the month stated on the packaging. Do not throw away any medicines via wastewater or household waste.

 

Important information

This product is a medicine; make sure to speak to your doctor or Chemist4U pharmacist before taking this product if you have an underlying medical problem or are taking any other medicine or complementary therapy. If your symptoms get worse or continue after taking this product, contact us or your doctor. For medical services in your area, please refer to https://www.nhs.uk

If you are pregnant, trying to become pregnant, or breastfeeding, speak to your doctor or Chemist4U pharmacist before taking this product. If you suffer from any allergies, ask your doctor or Chemist4U pharmacist if this medicine is right for you.

Store all medicines out of sight and reach of children.

Please read the included leaflet carefully before taking this product.

Please contact your GP if appropriate regarding this product.

Promethazine Hydrochloride 25mg - 56 Tablets Reviews

white-star white-star white-star white-star white-star
By Tony Roberts,
March 25, 2026
It helps me sleep on the days that I cannot especially after a long shift at work I usually cut the tablet in half
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By OICWOICW,
March 24, 2026
One of the few things that will actually help me sleep.
white-star white-star white-star white-star white-star
By Constantina Stanciu,
March 24, 2026
Extremely effective for insomnia! I used less than half a pill a night and now I can sleep through the night for 7/8 hours
white-star white-star white-star white-star white-star
By Catherine,
March 24, 2026
Amaising little things. I'm now getting between 6 and 7 hours the last 3 night from 3 hours if I'm lucky
white-star white-star white-star white-star white-star
By Lyn,
March 17, 2026
Suffer with with allergies and tried everything else nothing else worked

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