Adapalene/Benzoyl Peroxide Gel

What adapalene/benzoyl peroxide gel?

Adapalene/benzoyl peroxide gel is a topical acne treatment that combines two active ingredients to help manage breakouts and improve your skin over time.

The gel contains:

• Adapalene 0.1%, a retinoid that helps your skin renew and prevents pores from becoming blocked.
• Benzoyl peroxide 2.5%, an antibacterial ingredient that reduces acne-causing bacteria.

Together, these ingredients target multiple causes of acne, including blocked pores, excess oil, and inflammation.

This combination treatment is often prescribed when single treatments have not been effective enough.

Is adapalene/benzoyl peroxide gel the same as Epiduo?

Yes. Adapalene/benzoyl peroxide gel is the same active treatment as Epiduo, which is a branded version of the same combination.

Both contain adapalene and benzoyl peroxide and work in the same way. The main difference is branding and packaging.

Generic versions may be available at a lower cost while providing the same clinical effect.

How does adapalene/benzoyl peroxide gel work?

This treatment works by combining two complementary actions that target the root causes of acne.

Adapalene helps regulate how your skin cells renew, preventing dead skin from blocking pores. This reduces the formation of blackheads and whiteheads.

Benzoyl peroxide works by killing acne-causing bacteria on your skin and reducing inflammation. It also helps remove excess oil and keeps pores clear.

Together, they:

• prevent clogged pores
• reduce bacteria on the skin
• calm inflammation
• help stop new breakouts from forming

Because it targets multiple causes of acne at once, this combination treatment can be more effective than using a single ingredient alone.

How long does it take to work?

You may begin to see improvement after 2-4 weeks of using adapalene/benzoyl peroxide gel, but it can take 8-12 weeks to see the full benefits.

It is common for your acne to appear worse at first. This is sometimes called ‘purging’ and happens as blocked pores clear. This phase is usually temporary.

Consistency is key. Using the treatment regularly, as directed, yields the best results over time.

How effective is adapalene/benzoyl peroxide gel?

Adapalene/benzoyl peroxide gel is considered an effective treatment for mild to moderate acne when used consistently.

Clinical guidance from the National Institute for Health and Care Excellence (NICE) recommends fixed‑combination topicals (retinoid + benzoyl peroxide or antibiotic) as part of the first‑line options for mild–moderate acne.

Many people notice:

• fewer breakouts
• reduced redness and inflammation
• smoother skin texture over time

However, the effectiveness depends on regular use and following a suitable skincare routine.

How to use adapalene/benzoyl peroxide gel

This treatment is usually applied once daily in the evening. You should:

• Wash your face with a gentle cleanser and pat dry.
• Apply a thin layer of gel to the affected area.
• Avoid the eyes, lips, and sensitive areas.
• Wash your hands after application.

Top tips for using adapalene/benzoyl gel:

• Use a moisturiser to reduce dryness.
• Apply sunscreen daily, as your skin may be more sensitive to sunlight.
• Avoid using other harsh skincare products at the same time.

You can find out more in the patient information leaflet.

Can I leave adapalene/benzoyl peroxide gel on overnight?

Yes. Adapalene/benzoyl peroxide gel is designed to be left on your skin overnight.

Applying it in the evening allows it to work while your skin naturally renews. You should wash it off the next morning as part of your skincare routine.

Potential adapalene/benzoyl peroxide gel side effects

Side effects are common when starting treatment but are usually mild and improve over time.

Common adapalene/benzoyl peroxide gel side effects include:

• dry skin
• redness
• peeling
• mild irritation or burning sensation

These effects are usually temporary and can be managed with moisturiser and gradual use.

Seek medical advice if you experience

• severe skin irritation
• swelling or blistering
• signs of an allergic reaction

If side effects are severe or persistent, speak to your healthcare provider.

Who shouldn’t use adapalene/benzoyl peroxide gel?

This treatment may not be suitable for you if you:

• are pregnant or planning a pregnancy
• have very sensitive or damaged skin already
• are allergic to adapalene or benzoyl peroxide

You should also avoid using it alongside certain treatments unless advised by a healthcare professional.

Always check with your pharmacist or doctor if you are unsure. There may be different acne treatment options better suited to your needs and medical history.

Storage information

• Store below 25°C.
• Keep the tube tightly closed.
• Protect from heat and direct sunlight.
• Keep out of reach of children.

Do not use after the expiry date.

Alternatives to adapalene/benzoyl peroxide gel

If this treatment is not suitable for you, there are both medical and non-medical alternatives available.

Medical alternatives

If you’re looking for a different treatment, you could consider:

• Differin, which only contains adapalene
• benzoyl peroxide-only treatments
• topical antibiotics for acne
• oral treatments for more severe acne

Non-medical options

Non-medical alternatives include:

• gentle skincare routines
• oil-free, non-comedogenic products
• avoid picking or squeezing spots
• light therapy

Your healthcare provider can help you choose the most suitable option for your skin.

Adapalene/benzoyl peroxide gel vs Differin

The main difference between adapalene/benzoyl peroxide gel and Differin is that Differin only contains adapalene. Since the combination gel includes an antibacterial ingredient, it can be more effective for inflammatory acne compared to Differin’s adapalene-only treatment.

Frequently asked questions about adapalene/benzoyl peroxide gel

Does adapalene push out blackheads?

Yes. Adapalene helps increase skin cell turnover, which can bring blocked pores to the surface. This may look like worsening acne at first, but it usually improves with continued use.

Do I put on adapalene at night or in the morning?

It is usually applied at night, as sunlight can increase skin sensitivity. Applying it in the evening also allows it to work alongside your skin’s natural renewal cycle.

Can I use moisturiser after adapalene gel?

Yes. Using a moisturiser can help reduce dryness and irritation. It is often recommended to apply moisturiser after the treatment has absorbed.

Sources

• Adapalene/Benzoyl Peroxide Gel PIL. EMC. [Accessed 9 April 2026].
• Acne. (2023). NHS. [Accessed 9 April 2026].
• Acne vulgaris: management (NG198). (2021). NICE. [Accessed 9 April 2026].