- Topical treatment for mild to moderate acne.
- Contains adapalene.
- Always read the patient information leaflet before use.




Buy Differin Cream
Differin Cream treats mild to moderate acne on the face, chest or back.
How Differin Cream works
Differin Cream contains adapalene, which increases skin cell turnover, aiding the natural exfoliation of the skin and helping to unblock pores. As a result, spots or pimples are prevented from forming under the skin.
Directions
Always use Differin Cream exactly as described in the patient information leaflet or as your doctor / Chemist4U pharmacist has told you.
Differin should be applied at night before going to bed.
Thoroughly wash the affected area with water. Once your skin is clean and dry, apply a thin film of the cream and rub it in gently with your fingertips.
How long it takes for Differin to clear acne varies from person to person. Once you’ve been using Differin for 3 months, you will need to speak to your doctor or Chemist4U pharmacist so they can check on your skin’s improvement.
You mustn’t exceed the recommended dose of Differin as your acne will not improve any quicker, and your skin may become irritated and red.
Side effects
Like all medicines, Differin Cream may cause side effects in some people, but these won’t affect everybody. Common side effects may include:
- Dry skin
- Skin irritation
- Burning sensation of the skin
- Redness of the skin (erythema)
If you experience any side effects, including any not included in the patient information leaflet, you can report them using the MHRA Yellow Card Scheme.
Serious side effects
Seek emergency medical attention if you notice any signs of a severe allergic reaction, symptoms of which include swelling of the face and throat, skin rash, breathing difficulties and/or loss of consciousness.
Warnings
Differin Cream may be unsuitable for certain people. Do not use this product if you are allergic to any of the ingredients.
Do not use this medicine if you suffer from eczema.
Differin Cream must not be used on areas where the skin is cut, scraped or sunburnt.
Using/taking other medicines
If you are taking or have recently taken any medication, including medication obtained without a prescription, talk to your GP or pharmacist before using this product.
Age restrictions
Unfortunately, we are unable to prescribe this product from our clinic to anyone under the age of 18 or over the age of 75.
Pregnancy and breastfeeding
Do not use this product if you are pregnant or trying to get pregnant. If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, you must ask your doctor or Chemist4U pharmacist for advice before using any new medicine.
Storage information
Store below 25°C in a cool, dry place out of sight and reach of children. Do not use after the expiry date, referring to the last day of the month stated on the packaging. Do not throw away any medicines via wastewater or household waste.
Important information
This product is a medicine; make sure to speak to your doctor or Chemist4U pharmacist before using this product if you have an underlying medical problem or are taking any other medicine or complementary therapy. If your symptoms get worse or continue after using this product, contact us or your doctor. For medical services in your area, please refer to the NHS website.
If you are pregnant, trying to become pregnant, or breastfeeding, speak to your doctor or Chemist4U pharmacist before using this product. If you suffer from any allergies, ask your doctor or Chemist4U pharmacist if this medicine is right for you.
Store all medicines out of sight and reach of children.
Please read the included leaflet carefully before using this product.
Please contact your GP if appropriate regarding this product.
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How long does it take for Differin to work?
Results will vary from person to person, but typically there should be some improvement after a week of use.
Sometimes, a couple of weeks into treatment the acne may return as the medicine gets to work on clogged pores in the lower layers of the skin.
This doesn’t mean your skin is getting worse, as it will clear up within a couple of months in most cases.
What is acne?
Acne is a skin condition that can happen to anyone but is especially common in children and young adults.
Acne happens when the glands in the surface of your skin start to produce too much of an oil named sebum, which can clog your follicles, causing spots, whiteheads, blackheads, and more.
It’s caused by hormonal changes, like those that happen during puberty, pregnancy, or throughout your period.
When you have acne, your skin will produce too much oil or sebum, which then clogs your pores and causes breakouts.
When combined with this excess oil, the bacteria that live on your skin can get aggravated, causing redness and inflammation alongside the spots and this whole combination can be sore and irritating.
Acne can be mild, causing just a few spots and blackheads, but can range all the way to severe acne, which can cause large, painful papules, cysts, and nodules on top of everything else.
Although people think acne is all about breakouts of spots, there are a couple of other symptoms you may experience when you have acne, including oily skin, or skin that’s sore or hot to touch.
Acne usually appears on your face, chest, or back, and it can be tempting to squeeze the spots that appear there, but you should resist the temptation and use an acne treatment to help you manage your condition effectively and avoid scarring.
Do I need a prescription for this medication?
You do need a prescription for this medication in the UK.
Our healthcare professionals can provide prescriptions if they think this treatment would be right for you and your condition.
When you click the button which reads “Start Consultation” at the top of this page, you’ll see a short questionnaire set up by our healthcare team which is designed to help them understand your medical needs.
Just like an in-person consultation with your GP, our doctors will assess your answers to their questions and write a prescription for the treatment they think will be best for you.
You’ll then be able to pay for your medication and we’ll send it out to you quickly and in discreet packaging.