Nytol One-A-Night 50mg - 20 Tablets

Based on 37 reviews
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One-A-Night £7.89
Alexandra Moses - Medical Content Writer
Alexandra Moses
Medical Content Writer
James O'Loan - CEO & Superintendent Pharmacist
James O'Loan
CEO & Superintendent Pharmacist

Buy Nytol One-A-Night

Nytol-One-A-Night contains the active ingredient diphenhydramine hydrochloride, an antihistamine that causes sleepiness or drowsiness. This medicine can be used to treat short-term insomnia caused by various problems such as stress, jet lag or personal problems such as a bereavement. 


Nytol One-A-Night has been shown to help sufferers to fall asleep faster, have a longer and deeper sleep, and to wake up feeling well rested in the morning. It reduces alertness and promotes the first drowsy stage of sleep.



Always take Nytol One-A-Night exactly as described in the patient information leaflet or as your doctor / Chemist4U pharmacist has told you. For adults and children aged 16 years and over, swallow 1 tablet with water 20 minutes before you go to bed. Do not take more than the recommended dose. Do not take extra tablets if you wake up in the night. 


Age restrictions 

Nytol One-A-Night is unsuitable for children under the age of 16. If you’re looking for a short-term insomnia treatment for a child under the age of 16, you must speak to your doctor or Chemist4U pharmacist for advice on alternative treatment options.


Pregnancy and breastfeeding 

If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, you must ask your doctor or Chemist4U pharmacist for advice before taking any new medicine. 


Driving and machinery 

Do not drive or operate machinery while taking this medicine. Nytol One-A-Night is intended to produce sleepiness or drowsiness soon after the dose is taken.



Do not drink alcohol while using Nytol One-A-Night.


Do not take Nytol One-A-Night 

Nytol One-A-Night may be unsuitable for certain people. Do not take these tablets if you are allergic to diphenhydramine hydrochloride or any of the other listed ingredients. Do not take these tablets if you have an obstruction in your stomach or gut (for example, because of an ulcer). 


Talk to your doctor or Chemist4U pharmacist before taking this medicine if you have any of the following:


  • If you are taking any prescribed medicines; particularly tricyclic antidepressants, monoamine oxidase inhibitors (MAO Is prescribed for depression) within the last two weeks, atropine (used to dilate pupils of the eyes) or medicines which make you drowsy. Avoid the use of other antihistamines including those used on your skin and in cold and cough medicines, while taking this medicine 
  • If you have been told by your doctor that you have an intolerance to some sugars
  • If you have asthma, bronchitis or Chronic Obstructive Pulmonary Disease (COPD)
  • If you have narrow-angle glaucoma (a form of raised pressure in the eye)
  • If you have an enlarged prostate or urinary retention
  • If you have moderate to severe liver or kidney disease
  • If you have myasthenia gravis, epilepsy or seizure disorders



Side effects

Like all medicines, Nytol One-A-Night may cause side effects in some people, but these won’t affect everybody. Common side effects include: 


  • Tiredness and drowsiness
  • Reduced attention
  • Unsteadiness
  • Dizziness
  • Dry mouth 


For more information on potential side effects, refer to the patient information leaflet. If you experience any side effects, including any not included in the patient information leaflet, you can report them using the MHRA Yellow Card Scheme.


Serious side effects

Seek emergency medical attention if you notice any signs of a severe allergic reaction, symptoms of which include swelling of the face and throat, skin rash, breathing difficulties and/or loss of consciousness.


Storage information

Store in a cool, dry place out of sight and reach of children. Do not use after the expiry date, referring to the last day of the month stated on the packaging. Do not throw away any medicines via wastewater or household waste.


Important information

This product is a medicine; make sure to speak to your doctor or Chemist4U pharmacist before taking this product if you have an underlying medical problem or are taking any other medicine or complementary therapy. If your symptoms get worse or continue after taking this product, contact us or your doctor. For medical services in your area, please refer to https://www.nhs.uk

If you are pregnant, trying to become pregnant, or breastfeeding, speak to your doctor or our pharmacist before taking this product. If you suffer from any allergies, ask your doctor or our pharmacist if this medicine is right for you.

Store all medicines out of sight and reach of children.

Please read the included leaflet carefully before using this product.

Please contact your GP if appropriate regarding this product.


Helpful Advice on Medication Restrictions & Addiction

For further information on our medication restrictions policy, please click here.

If you are concerned about addiction to 'over the counter' medication, we urge you to visit the below links for professional help and advice:

NHS Help & Advice on Drug Addiction

Talk To Frank - Drug Addiction Help & Support


Nytol One-A-Night 50mg - 20 Tablets Reviews

April 16, 2024
Really good for temporary use - helps me to Fall to sleep if I’m Struggling
By Kelly Savov,
March 19, 2024
Great product.
By Barrie Todd,
March 19, 2024
Does what it says on the packet
By Paul,
February 27, 2024
Much more effective than the herbal version. These really do work, for me at least! Work is very stressful at the moment and these really help to calm my thoughts down enabling a much better sleep.
By Margaret Darroch,
December 13, 2023
Got this item to try n get into a sleep routine

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