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Nytol One-A-Night - 20 x 50mg Tablets

Availability: In stock

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To Purchase this product, you will need to answer a medical questionnaire after you select 'add to basket'
Limited to 2 per order
Free Delivery
Over £30
Discreet Delivery
Nytol One-A-Night - 20 x 50mg Tablets

Availability: In stock

Warning Maximum Product Quantity of 2
  • • Works by blocking the normal actions of histamine
  • • Helps to reduce alertness and promote the first drowsy stage of sleep
  • • Clinically proven to relieve sleeping difficulties, formulated to help with insomnia
  • • Contains lactose, ask your doctor before taking this medicine
  • • Active Ingredient: Diphenhydramine
  • • You will be asked to answer some medical questions before purchase, to check if your condition is suitable for this medicine
 To Buy This Product You Must Answer the Below Questions
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Some medication licenses are restricted by gender. Transgender patients must select their biological gender - we apologise to any patients with objections. If you are transgender please contact us after registering if required

(Please describe typical symptoms even if you are not currently suffering from them)

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  • I will fully read the leaflet provided with this product
  • I will inform my own GP of this purchase if appropriate
  • All of the information provided is truthful and correct.
  • I agree to the terms and conditions on this website.
  • I consent to being assessed and treated online via this platform
  • I consent to having medicines delivered to my chosen shipping address and I have risk assessed this address to ensure children, vulnerable individuals or pets cannot access the delivery.


Warning: if the above criteria cannot be met or doesn’t apply to the intended user, this product would not be appropriate for use. If you have any queries please contact one of our healthcare team.
Warning Maximum Product Quantity of 2

Nytol One-A-Night - 20 x 50mg Tablets


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What is Nytol One-A-Night and when is it used?

This medicine is an antihistamine used to help you relax and fall asleep, it reduces alertness and promotes that first drowsy stage of sleep, helping you to then drift off into a restful, deeper sleep.

Use it when you want to fall asleep, as this medication will make you feel drowsy and help you to drop off for a good night’s sleep.


Why is Nytol One-A-Night right for me?

Nytol One-A-Night Tablets are the perfect solution for those who are suffering from short-term insomnia. If you’re sick of laying in bed staring at the ceiling all night, these tablets can help you to finally get some much-needed rest.


Why can’t I fall asleep?

Sometimes a sleepless night happens for no reason, but if you regularly struggle to fall asleep and stay asleep, then you may be suffering from insomnia. Some of the most common causes of insomnia are anxiety, stress, and depression, which can be made even worse if you’re struggling to get a good night’s sleep. You may also experience insomnia due to physical health conditions, side effects of medication, or other external factors such as jet lag, or having noisy neighbours.


How will Nytol One-A-Night treat my symptoms?

Nytol One-A-night tablets work as an antihistamine, which means that they block the normal actions of histamine, a natural chemical in your body which stimulates areas of your brain which promote arousal. Each tablet contains 50mg of an ingredient called diphenhydramine hydrochloride, which blocks histamine, reducing alertness and helping you to fall into the first drowsy stage of sleep, leading to the good night’s rest that you deserve.


Can I take this product if I’m pregnant or breastfeeding?

If you are pregnant, trying to become pregnant, or breastfeeding, consult your doctor before taking Nytol One-A-Night. This medication may not be the best choice for you and your baby at this time, and a medical professional can help you to choose a treatment that is safe for both of you.


Can I drive after taking these tablets?

Nytol One-A-Night is designed to make you feel sleepy, so do not drive or use any machinery or tools after taking this product unless you are sure that you are not affected in this way.


Can I drink alcohol while I’m taking these tablets?

You should not drink alcohol while taking these tablets or any other antihistamines. It can increase the effects of this product and make it more difficult to manage.


Can I take these tablets if I’m taking other medication?

You should speak to your doctor or Chemist 4 U pharmacist before using this product if you are taking any other medication, including those you obtained without a prescription. Some medications can interact when used together, causing unwanted side effects or making your medication less effective. You should particularly be sure to speak to your doctor if you are taking:

  • Tricyclic antidepressants, e.g. Amitriptyline, Amoxapine, Desipramine
  • Monoamine Oxidase Inhibitors (MAOIs), which are used for depression, e.g. Isocarboxazid (Marplan), Phenelzine (Nardil), Selegiline (Emsam)
  • Atropine, which is used to dilate the pupils of the eyes
  • Medicines which make you feel drowsy
  • Antihistamines, including those used on the skin and those in cold and cough medicines


How do I take Nytol One-A-Night?

Swallow one Nytol One-A-Night tablet with water 20 minutes before you go to bed. If you wake up in the night, do not take any more tablets and do not take more than the recommended dose. Do not take these tablets for more than 2 weeks without speaking to a doctor.


Do I need a prescription for Nytol One-A-Night?

You do not need a prescription for Nytol One-A-Night, however, you will be asked to complete a short medical questionnaire by your Chemist 4 U pharmacist before we can take your order. This includes some simple questions that all pharmacies legally are required to ask before supplying this kind of product. This helps our pharmacy team to be sure that this product is the best choice for you.


When should Nytol One-A-Night not be used?

Nytol One-A-Night is not suitable for use by anyone under the age of 16, or an elderly person who suffers from confusion. Do not take this product if you are allergic to diphenhydramine hydrochloride or any of the other listed ingredients. These tablets contain lactose, you should consult your doctor or Chemist 4 U pharmacist before use if you have been told that you are intolerant to some sugars. Do not use this product if you have an obstruction in your stomach or gut, e.g. because of an ulcer. Speak to your doctor or Chemist 4 U pharmacist before using this product if you:

  • Have asthma, bronchitis, or Chronic Obstructive Pulmonary Disease (COPD)
  • Have narrow-angle glaucoma, a form of raised pressure in the eye
  • Have an enlarged prostate or urinary retention
  • Have moderate to severe liver or kidney disease
  • Have myasthenia gravis, epilepsy, or seizure disorders


Does this product have any side effects?

Like all medication, Nytol One-A-Night may produce side effects, although you may not experience them. These include:

  • Drowsiness
  • Tiredness
  • Reduced attention
  • Unsteadiness
  • Dizziness
  • Dry mouth
  • Allergic reactions, e.g. rash, shortness of breath, swelling
  • Blurred vision
  • Palpitations or irregular heartbeat
  • Muscle twitching, convulsions, headache or pins and needles
  • Nausea, vomiting, thicker bronchial mucus, difficulty passing urine

If you experience these or any other side effects while taking Nytol One-A-Night, stop use and speak to your doctor or Chemist 4 U pharmacist. For more information about reporting the side effects of medication, please see the MHRA’s Yellow Card Scheme.


How to store this product

Store in a cool, dry place. Store in original packaging and do not use this product if the expiration date printed on the packaging has passed. Keep out of sight and reach of children.


Important Information

This product is a medicine; make sure to speak to your doctor or Chemist 4 U pharmacist before taking this product if you have an underlying medical problem or are taking any other medicine or complementary therapy. If your symptoms get worse or continue after taking this product, contact us or your doctor. For medical services in your area, please refer to

If you are pregnant, trying to become pregnant, or breastfeeding, speak to your doctor or our pharmacist before taking this product. If you suffer from any allergies, ask your doctor or our pharmacist if this medicine is right for you.

Store all medicines out of sight and reach of children.

Please read the included leaflet carefully before using this product.

Please contact your GP if appropriate regarding this product.


Helpful Advice on Medication Restrictions & Addiction

For further information on our medication restrictions policy, please click here.

If you are concerned about addiction of 'over the counter' medication we urge you to visit the below links for professional help and advice:

Swallow One tablet with water 2 minutes before you go to bed.
Do not exceed the stated dose.
Do not give to children under 16 years of age.

Do not take:

If you have ever had an allergic reaction to diphenhydramine hydrochloride or any of the other ingredients.

If you have an obstruction in your stomach or gut for example, because of an ulcer.

If you are pregnant, breast feeding or receiving prescribed medicines.

If your sleeping difficulties persist, see your doctor.

Warning: this medicine may make you sleepy. If this happens do not drive or use tools or machines. Do not drink alcohol.

Keep out of the sight and reach of children

- The active substance: Each tablet contains Diphenhydramine Hydrochloride 50 mg.

- The other ingredients are: Anhydrous lactose, microcrystalline cellulose, maize starch, stearic acid and silicon dioxide.

Shipping Costs

Free UK Delivery on all orders over £30 - Delivery within 3-5 working days

Standard UK Delivery - £2.95 - Delivery within 3-5 working days


Please Note: These prices are shown as a guide only. All delivery times are approximate but have been obtained in good faith.


Discreet Delivery

All our items are sent completely discreet for your peace of mind.

This means the packaging is plain, there is no mention of what product is inside your package and there is no mention of Chemist 4 U either.

We respect that many of our products are of a sensitive nature - this is why we take every step to keep your purchases private.


Returns Information

Customers can read our full returns policy by clicking here

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