Mini Pill vs Combined Pill: Which is Right For You?  

The combined and mini (POP) birth control pills are both hormonal methods of contraception taken daily. The combined pill contains oestrogen and progestogen, while the mini pill only contains progestogen

Most people can take either the mini or combined birth control pills with no problems or side effects, and the same level of protection when it comes to preventing pregnancy.  

However, individual risk factors, pre-existing health conditions, your lifestyle and, honestly, how good you are at remembering to take medication can all influence which type of pill you go for.  

Our guide has everything you need to know about the combined pill and mini pill, so you can make a decision you feel confident in.  

Three key takeaways  

  • While both forms of pill have minimal side effects, the mini pill has fewer.  
  • The mini pill is suitable for a wider range of people, as it doesn’t contain oestrogen. 
  • Whichever form of pill you take, it’s important to remember to take it correctly. This means at the same time each day, and as directed by your clinician. 

Combined pill vs mini pill

Mini pill vs combined pill at a glance  

 Mini pill Combined pill 
Example pills Cerazette
Cerelle
Desogestrel
Hana
Norgeston
Noriday 
Lucette
Microgynon 30
Rigevidon
Yasmin 
Active ingredient(s) Synthetic progestogen (exact hormone varies) Synthetic oestrogen and progestogen (exact hormones vary) 
When to take (frequency) One pill at the same time every day  One pill at the same time every day 
How to take  No break between packs. If your pill is an everyday pill, take every day. 
If your pill is a 21-day pill, take for 21 days, then have a break for seven days.  
Effectiveness (perfect use)  Over 99% Over 99% 
Effectiveness (typical use)  91% 91% 
Common side effects (may affect up to one in 10 women)  May make your periods lighter or heavier
Mood changes
Decrease in sex drive
Headache
Nausea 
Acne 
Breast pain
Weight change  
Breakthrough bleeding
Headache
Mood changes
Migraine
Nausea
Vaginal discharge 
Uncommon side effects (may affect up to one in 100 women)  Infection
Difficulties with contact lenses
Hair loss
Vomiting 
Painful periods
Ovarian cysts
Tiredness 
Breast enlargement
Change in blood pressure
Vomiting
Diarrhoea
Acne, skin rash, itching
Hair loss 
Vaginal infection
Fluid retention 
Rare side effects (may affect up to one in 1,000 women)  Rash
Hives 
Skin lumps 
Allergic reaction
Breast secretion
Hearing loss
Asthma
Rashes
Blood clots 

Mini pill explained  

The mini (or POP) pill contains only progestogen. There are three types, which have different ingredients. These are:  

  • 3-hour progestogen-only pill: the active ingredients in these birth control pills are norethisterone or levonorgestrel. Each pill needs to be taken within three hours of the same time every day. Brands include Norgeston and Noriday.  
  • 12-hour progestogen-only pill: these pills contain desogestrel. You can take this pill within 12 hours of the same time every day. Brands include Cerazette, Cerelle and Hana.  
  • Drospirenone pills: these pills are generally given to people who find desogestrel isn’t the right fit. Brands include Slynd. Slynd has a 24-window of effectiveness, though it’s still recommended that you take it at the same time every day.  

How does the mini pill work?  

The mini pill works by:  

  • stopping your ovaries releasing eggs (if it contains desogestrel or drospirenone; older mini pills may not consisently stop ovulation)
  • thickening your cervical mucus to make it harder for sperm to reach an egg  
  • thinning your womb lining to prevent any fertilised egg from implanting into your uterus. 

How effective is the mini pill?  

Like the combined pill, the mini pill is 99% effective when taking perfectly. However, when allowing for human error like missed pills, or sickness, that number drops to 91%.  

How to take the mini pill  

Whatever brand you pick, you need to take your mini pill every day. However, your exact routine depends on what kind of mini pill you have: 

  • 3-hour progestogen-only pill: should be taken within three hours of the same time every day without breaks.  
  • 12-hour progestogen-only pill: can be taken within 12 hours of the same time every day. Each pack contains 28 or 35 pills and should be taken without a break between packs.  
  • Drospirenone pills: have a wider window of 24 hours, but should be taken at the same time every day. Each pack contains active and inactive pills, and should be taken without a break.  

What to do if you miss a mini pill 

No-one is perfect, and it’s easy to forget to take your pill. If you miss one, take another immediately, even if that means two pills in one day. 

Your level of protection depends on how long it’s been since your missed pill:  

  • If you miss your 3-hour progestogen-only pill by more than three hours, you are not protected. Take another pill, and continue the rest of the pack. Use condoms or a barrier method of contraception, or don’t have sex for two days.  
  • If you miss your 12-hour progestogen-only pill by more than 12 hours, you are not protected. Take another and continue your pack as usual. For the next two days, use a barrier form of contraception or don’t have sex.  
  • If you miss your drospirenone pill by more than 24 hours, take another as soon as you remember and use condoms for seven days. If the pill you skipped was one of the last seven active pills, skip the dummy pills and go straight to your next pack.  

If you’re unsure about your level of pregnancy protection, or whether you need to use emergency protection, speak to your clinician.  

Common side effects of the mini pill  

Brands of the mini birth control pill differ, so side effects can vary. However, up to one in 10 people experience the following.  

  • lighter or heavier periods
  • mood changes 
  • decrease in sex drive 
  • headache 
  • nausea  
  • acne  
  • breast pain 
  • weight change 

Combined pill explained  

The combined pill contains synthetic oestrogen and progestogen.  

There are three basic kinds of combined pills, which are taken in different ways. These are:  

  • Monophasic 21-day pills: each pill contains the same amount of hormones. You take 21 pills followed by a seven-day break. Common brands include Microgynon 30, Yasmin and Lucette.  
  • Multiphasic: each pack has two or three sections of pills in different strengths. Brands include Logynon and Synphase.  
  • Every day (ED) pills: each pack contains 28 pills. This could be 21 active and seven dummy pills or 24 active and four inactive pills.  

How does the combined pill work?  

The combined pill prevents pregnancy in three ways:  

  • Prevents ovulation: you stop releasing eggs each month.  
  • Thickens cervical mucus: making it harder for sperm to reach an egg. 
  • Thins the womb lining: to prevent any fertilised egg from implanting into your uterus.  

How effective is the combined pill?  

Used exactly as directed (known as perfect use), combined pills are over 99% effective

However, 'typical use' allows for human error like missed or late pills, and illnesses such as vomiting or having diarrhoea. When this is taken into account, combined pills are 91% effective. This means every year nine users will get pregnant while on the pill. 

You can find how more about how reliable birth control is with our expert guide.  

How to take the combined pill  

Combined pills are taken every day. Each form of pill has a different regime.  

  • Everyday (ED) pill should be taken every day.  
  • 21-day pills need to be taken for three weeks, followed by a one week break.  
  • Multiphasic pills are taken in a colour-coded order, usually for 21 days, with a 7-day break.  

Whichever form of combined pill you choose, it’s important to follow the instructions in the leaflet or talk to your doctor or prescriber about how to take your brand.  

What to do if you miss a combined pill 

If you have missed one pill, you should:  

  1. Take the last pill you missed, even if that means having two pills in one day. 
  1. Continue the pack. 
  1. Take your break as usual. 

You will not have to use additional contraception. However, if your missed pill is at the start or end of your menstrual cycle, you may want to use extra protection or abstain for sex for seven days. This is because it can extend the hormone-free window and put you at a higher risk of getting pregnant.  

If you’ve missed two or more pills: 

  1. Take the last pill you missed as soon as you remember. 
  1. Continue the pack.  
  1. Use additional barrier contraception, like a condom or the cap, for seven days.  
  1. If these seven days run beyond the end of the pack, you should start the next pack straight away, without a break or use of placebo pills (depending on your choice of pill). 

Common side effects of the combined pill  

The side effects of the combined pill can vary depending on which brand you take. However, one in 10 users experience the following.  

  • breakthrough bleeding 
  • headache 
  • mood changes 
  • migraine 
  • nausea 
  • vaginal discharge 

Advantages and disadvantages of the combined pill vs mini pill  

 Combined pill  Mini pill  
Potential for side effects  Side effects more likely.  Fewer side effects. 
Periods  Replaces your period with a withdrawal bleed. It’s safe to take packs continuously and avoid bleeding.  Periods can become lighter or stop.  
Reduces risk of some cancers  Studies show those taking the combined pill are less likely to get ovarian, uterine and bowel cancers.  There are fewer definitive studies. But some studies indicate the mini pill may decrease the risk of endometrial cancer.  
Can help with acne  Yasmin or Lucette can help prevent flare-ups.  No.   
Can reduce symptoms of polycystic ovary syndrome (PCOS) and endometriosis  Yes, when taken back-to-back.  Yes  
May raise blood pressure  Can cause high blood pressure.  Highly unlikely to cause raised blood pressure.  
Suitable for smokers over 35? Less suitable  Yes 
May be risky for those who get migraines   Yes No 
Risk of ectopic pregnancy Slightly higher on hormonal contraceptive.  Slightly higher on hormonal contraceptive.  
Risk of blood clots  Small increase in risk.  No increase in risk. 

How to choose between the combined pill and mini pill 

“The best contraceptive pill for your needs depends on what you want to get out of your birth control.  

“If you just want to prevent pregnancy, and don’t have any other concerns, then the combined pill and mini pill are just as effective as each other.  

“But if you have specific things you’re looking for from your contraception, your choice of pill matters. For example, if you want to use it to stop your periods, the mini pill might be your best bet. However, if you’re after something that can help with acne flare-ups, specific versions of the combined pill are going to be more suitable.  

“During your consultation with Chemist4U, we can answer all your questions and help you find a pill that fits with what you want beyond just preventing pregnancy.” 

Hanna Yusuf, Prescribing Pharmacist at Chemist4U 

Hanna Yusuf, Prescribing Pharmacist

Free contraception with Chemist4U  

Chemist4U can help with your free NHS contraception, with no GP appointment needed! 

Most popular oral contraceptives are available through this service, including both combined and progesterone-only (mini pill) options and emergency contraception.   

To ensure your choice of birth control is right and safe for you, our clinicians require a phone call with one of our friendly pharmacists after you’ve completed the online consultation.   

Frequently asked questions about the mini pill vs combined pill  

Is the mini pill better than the combined pill?  

Neither the mini pill or combined pill is 'better'. It just depends what you’re looking for. Factors that might influence your choice include existing health conditions, whether you smoke, how old you are, your BMI and which side effects you want to avoid. It could take a few trial runs to find the perfect contraceptive pill for you.  

Who cannot use progestin-only pills?  

Certain conditions, medical histories and medications might mean you shouldn’t take the mini pill. These include: 

  • some cancers 
  • liver diseases and conditions 
  • blood circulation issues
  • pregnancy
  • kidney conditions
  • conditions that affect absorption
  • taking medications including drugs for HIV, TB and seizure medications 

Sources 

Hanna Yusuf - Prescribing Pharmacist
Hanna Yusuf , Prescribing Pharmacist on 05 February 2026
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