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Ovranette (Combined Pill)

  • Combined contraceptive pill.
  • Contains levonorgestrel and ethinylestradiol.
  • Up to 99% effective at preventing pregnancy. 
  • Always read the patient information leaflet before use. 
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Checked for Accuracy by James O'Loan . CEO & Prescribing Pharmacist . on 20/09/2021

What is Ovranette?

Ovranette is a combined contraceptive pill for women containing the active ingredients levonorgestrel and ethinylestradiol. These ingredients are synthetic versions of the natural female sex hormones progestogen and oestrogen, which work to prevent pregnancy by stopping ovulation (the release of an egg from the ovaries), thickening the fluid in the cervix and keeping the lining of the womb thin enough to prevent an egg from growing. 

How should I take this pill? 

Ovranette comes in strips of 21 pills, each marked with a day of the week so it’s easier for you to keep track. Swallow each pill whole with water if needed - do not try to crush or chew the tablets. You should take one pill per day, at the same time each day, until you’ve taken all of the 21 pills in the strip. 

Once you’ve taken all 21 pills, you should have a seven-day break where you will take no pills at all. This will cause a withdrawal bleed similar to a period. If you’re still bleeding after the 7-day break and you’re due to start your next strip, you should still start this next strip as usual. 

What should I do if I miss a pill? 

If you were due to take a pill less than 12 hours ago, take the missed pill as soon as you remember, even if this means taking two pills in one day. You will still be protected from pregnancy in this case. 

If the pill you missed should have been taken more than 12 hours ago, or you’ve missed more than one pill, take the most recently missed pill straight away and leave any earlier missed pills in the strip. In this case, you will need to use another method of contraception for the next 7 days. If there are fewer than 7 pills left in the strip, skip the 7-day break and go straight onto your next strip after finishing your current one.

If you are sick or have severe diarrhoea within 4 hours of taking Ovranette, your body may not have absorbed the hormones in the pill. You should follow the instructions on what to do in the event of a missed pill. 

Starting Ovranette

The best time to start taking Ovranette for the first time is on the first day of your period. By starting your pill at this time, you will be protected from pregnancy straight away and you won’t need to use another method of contraception. If you start taking Ovranette on any other day, you should use barrier contraception, such as a condom, for the first 7 days of pill use. 

If you’re changing from a different type of hormonal contraception, such as another contraceptive pill or an implant, refer to the patient information leaflet about how to switch to Ovranette. 

How do levonorgestrel and ethinylestradiol prevent pregnancy?

Ovranette contains 150mg of the progestogen levonorgestrel and 30mg of the oestrogen ethinylestradiol. These hormones stop you from getting pregnant by preventing the release of an egg from your ovaries; making the fluid in your cervix thicker and therefore more difficult for sperm to get through into the womb; and by preventing the lining of your womb from becoming thick enough for an egg to grow. 

Is Ovranette suitable for pregnant or breastfeeding women?

You should not take Ovranette if you’re pregnant, or think you may be pregnant. You should speak to your doctor or Chemist4U pharmacist before taking Ovranette if you’re breastfeeding, to make sure it’s right for you and your baby. You may be advised not to take this pill. 

Can the pill be used to treat acne? 

Ovranette, and other combined contraceptive pills, are not specific treatments for acne. However, some doctors will prescribe a combined contraceptive pill to women who suffer from hormonal acne, as there does seem to be a beneficial effect. This is only the case with combined contraceptive pills like Ovranette, not progestogen-only mini-pills. It can take around 2-3 months of taking the pill before you may notice any effect on your acne. 

When should Ovranette not be used? 

Ovranette is a contraceptive treatment for females only - do not take this medication if you are male. You should also not take this medication if: 

  • You have or have ever had a blood clot in a blood vessel of your legs, lungs or other organs

  • You have any condition that makes you more at risk of a blood clot

  • You are 35 years or over and smoke 15 or more cigarettes a day

  • You have very high or uncontrolled blood pressure

  • You have an irregular heartbeat (atrial fibrillation) or a heart valve disorder 

  • You have migraines with visual disturbances

  • You have diabetes which has affected your circulation

  • You have systemic lupus erythematosus (SLE)

  • You have ever had liver tumours or severe liver disease and have been told by your doctor that your liver function tests are not yet back to normal

  • You have cancer affected by sex hormones, such as certain cancers of the breast or ovary 

  • You have unexplained vaginal bleeding

  • You are allergic to levonorgestrel, ethinylestradiol or any of the other ingredients in this medicine 

  • You have hepatitis C and are taking medicinal products containing ombitasvir/ paritaprevir/ritonavir, dasabuvir, glecaprevir/ pibrentasvir and sofosbuvir/velpatasvir/ voxilaprevir

If you are taking any other medicines or herbal remedies, including those obtained without a prescription, you should speak to your doctor or Chemist4U pharmacist before taking Ovranette. 

Some conditions can be made worse by taking Ovranette. You should take extra caution and speak to your doctor or Chemist4U pharmacist if any of the below conditions have ever applied to you: 

  • Problems with your heart, circulation or blood clotting, such as heart disease, high blood pressure for which you take medicines or diabetes

  • Liver problems or gallstones

  • High levels of cholesterol or lipids (fats) in the blood (hyperlipidaemia)

  • Migraines

  • Angioedema, symptoms of which include a swollen face, tongue or throat, difficulty swallowing, hives or difficulty breathing

  • Any illness that worsened during pregnancy or previous use of the pill

Refer to the patient information leaflet for more advice on who should or shouldn’t take Ovranette to see whether this medicine is suitable for you. 

Are there any side effects?

As with all medicines, Ovranette can cause side effects, but not everyone will get them. See a doctor straight away if you experience any symptoms of an allergic reaction, blood clots, heart attack or stroke, breast cancer, cervical cancer or severe liver problems. Information on the symptoms of these conditions can be found in the patient information leaflet. These side effects are rare but severe.

Other side effects can include: 

  • Headaches

  • Breakthrough bleeding or spotting

  • Infections of the vagina including thrush

  • Feeling or being sick

  • Stomach pain or cramps

  • Changes in weight

  • Change in mood including depression

  • Dizziness

  • Nervousness

  • Change in sex drive

  • Acne

  • Sore, painful or tender breasts

  • Changes in the secretion from the breast

  • Enlargement of the breasts

For further information on uncommon and rare side effects, refer to the patient information leaflet. If you experience any side effects, including any not included in the patient information leaflet, you can report them using the MHRA Yellow Card Scheme

Can Ovranette cause blood clots? 

Using a combined contraceptive pill like Ovranette can increase your risk of developing a blood clot. Whilst still rare, the risk is highest during the first year of taking the pill, and you should be aware of the symptoms. Seek emergency medical attention if you experience any of the following symptoms: 

  • Throbbing or cramping pain, swelling, redness and warmth in your leg or arm

  • Sudden breathlessness, sharp chest pain and a cough or coughing up blood 

For further information on the link between the combined contraceptive pill and blood clots, refer to the patient information leaflet. 

Can the pill increase the risk of breast cancer?

Breast cancer has been found slightly more often in women who take a contraceptive pill compared to women who don’t. Once you stop taking the pill, the risk gradually decreases and 10 years after stopping the pill the risk will be the same as someone who has never taken a contraceptive pill. Breast cancer is still rare for anyone under the age of 40, even in women who take the pill.

Do I need a prescription for Ovranette?

You do need a prescription for Ovranette in the UK. Our healthcare professionals can provide prescriptions if they think this treatment would be right for you and your condition. When you click the button which reads “Start Consultation” at the top of this page, you’ll see a short questionnaire set up by our healthcare team which is designed to help them understand your medical needs. Just like an in-person consultation with your GP, our doctors will assess your answers to their questions and write a prescription for the treatment they think will be best for you. You’ll then be able to pay for your medication and we’ll send it out to you quickly and in discreet packaging.

Storage information

Keep in the original packaging in a cool, dry area away from direct sunlight. Do not use this medicine after the expiry date printed on the packaging, referring to the last day of the stated month. 

Important information

This product is a medicine; make sure to speak to your doctor or Chemist4U pharmacist before taking this product if you have an underlying medical problem or are taking any other medicine or complementary therapy. If your symptoms get worse or continue after taking this product, contact us or your doctor. For medical services in your area, please refer to

If you are pregnant, trying to become pregnant, or breastfeeding, speak to your doctor or our pharmacist before taking this product. If you suffer from any allergies, ask your doctor or our pharmacist if this medicine is right for you.

Store all medicines out of sight and reach of children.

Please read the included leaflet carefully before using this product.

Please contact your GP if appropriate regarding this product.

Helpful Advice on Medication Restrictions & Addiction

For further information on our medication restrictions policy, please click here.

If you are concerned about addiction to 'over the counter' medication, we urge you to visit the below links for professional help and advice:

NHS Help & Advice on Drug Addiction

Talk To Frank - Drug Addiction Help & Support

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