Zyban MR Tablets

  • Tablets to help you stop smoking
  • Contains the active ingredient bupropion, which reduces nicotine cravings
  • Take 1 tablet daily, increased to 2 tablets daily after 7 days
Upon completion of a medical consultation with one of our health care professionals you can expect prices to start from £68.99
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All inclusive price starts from £68.99
The treatment is inclusive of consultation, private prescription & medicine delivery
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Alexandra Moses - Medical Content Writer
Alexandra Moses
Medical Content Writer
James O'Loan - CEO & Superintendent Pharmacist
James O'Loan
CEO & Superintendent Pharmacist

Buy Zyban MR Tablets 

Zyban is a medicine prescribed to help you stop smoking. Zyban will be most effective if you are fully committed to giving up smoking, such as taking part in a ‘stop smoking’ programme. It contains the active ingredient bupropion, a medication that works by reducing cravings for nicotine.



Always take Zyban Tablets exactly as described in the patient information leaflet or as your doctor / Chemist4U pharmacist has told you. You can take Zyban with or without food. Start taking Zyban while you are still smoking. You should set a target stop smoking day ideally during the second week you’re taking it.

During days 1-6, take 1 Zyban tablet (150mg) once a day. Once you reach day 7, increase your dose to 1 tablet, twice a day, at least 8 hours apart. You should not take a tablet close to your bedtime.

You should continue to take 1 tablet, twice a day for up to 9 weeks. If you have not been able to stop smoking after 7 weeks, you should stop taking Zyban and speak to your GP or Chemist4U pharmacist for advice. 


Side effects

Like all medicines, Zyban Tablets may cause side effects in some people, but these won’t affect everybody. Common side effects include: 


  • Difficulty in sleeping (make sure you don’t take Zyban near to bedtime)
  • Feeling depressed
  • Feeling anxious or agitated
  • Difficulty concentrating
  • Feeling shaky (tremor)
  • Headache
  • Nausea and vomiting 
  • Stomach pain or other upsets (such as constipation)
  • Changes in the taste of food
  • Dry mouth
  • Fever
  • Dizziness
  • Sweating
  • Skin rash
  • Itching 


For more information on potential side effects, refer to the patient information leaflet. If you experience any side effects, including any not included in the patient information leaflet, you can report them using the MHRA Yellow Card Scheme.


Serious side effects

Seek emergency medical attention if you notice any signs of a severe allergic reaction, symptoms of which include swelling of the face and throat, skin rash, breathing difficulties and/or loss of consciousness.

Approximately 1 in every 1,000 people taking Zyban is at risk of having a fit. Symptoms of a fit include convulsions and usually loss of consciousness. Someone who has had a fit may be confused afterwards and may not remember what has happened. 

Fits are more likely if you take too much Zyban, if you take some other medicines or if you are at higher than usual risk of fits. If you have a fit, tell your doctor when you have recovered. Don’t take any more Zyban.



Zyban may be unsuitable for certain people. Do not take these tablets if you are allergic to bupropion or any of the other listed ingredients. Do not take these tablets if any of the following apply to you:


  • If you are taking any other medicines which contain bupropion
  • If you have a condition that causes fits (seizures), such as epilepsy, or if you have a history of fits
  • If you have an eating disorder or had one in the past (for example, bulimia or anorexia nervosa)
  • If you have severe liver problems, such as cirrhosis
  • If you have a brain tumour
  • If you are usually a heavy drinker and you have just stopped drinking alcohol, or are going to stop while you’re taking Zyban
  • If you have recently stopped taking sedatives or medicines to treat anxiety (especially benzodiazepines or similar medicines), or if you are going to stop them while you’re taking Zyban
  • If you have a bipolar disorder (extreme mood swings) as Zyban could bring on an episode of this illness
  • If you are taking medicines for depression or Parkinson’s disease called monoamine oxidase inhibitors (MAOIs), or have taken them in the last 14 days. The timing may be shorter for some types of MAOIs, your doctor will advise you


Talk to your doctor or Chemist4U pharmacist before taking this medicine. This is because some conditions make it more likely that you will have side effects while taking this medicine.


Using/taking other medicines

Tell your doctor or Chemist4U pharmacist if you are taking, have recently taken or might take any other medicines, including medicines you bought without a prescription. 

There may be a higher than usual risk of fits if you take:


  • Medicines for depression or other mental health problems
  • Theophylline for asthma or lung disease
  • Tramadol, a strong painkiller
  • Medicines against malaria
  • Stimulants or other medicines to control your weight or appetite
  • Steroids (except creams and lotions for eye and skin conditions)
  • Antibiotics called quinolones
  • Some types of antihistamines mainly used to treat allergies, that can cause sleepiness
  • Medicines for diabetes


Some medicines can affect how Zyban works, or make it more likely that you’ll have side effects. These include:


  • Medicines for depression (such as desipramine, imipramine, paroxetine, citalopram, escitalopram, venlafaxine) or other mental health problems (such as risperidone, thioridazine). 
  • Medicines for Parkinson’s disease (such as levodopa, amantadine or orphenadrine)
  • Carbamazepine, phenytoin or valproate, to treat epilepsy or some mental health problems
  • Some medicines used to treat cancer (such as cyclophosphamide, ifosfamide)
  • Ticlopidine or clopidogrel, mainly used to treat heart disease or stroke
  • Some beta blockers (such as metoprolol), mainly used to treat high blood pressure
  • Some medicines for irregular heart rhythm (such as propafenone, flecainide)
  • Ritonavir or efavirenz, for treatment of HIV infection.


If you take any medicines on this list, check with your doctor or Chemist4U pharmacist. They will weigh up the benefits and risks to you of taking Zyban. 

Zyban may make other medicines less effective. For example, if you take tamoxifen used to treat breast cancer or digoxin for your heart, tell your prescriber. The dose of some medicines may need to be reduced when you stop smoking. 

When you smoke, the chemicals absorbed into your body can cause some medicines to be less effective. When you stop smoking, your dose of these medicines may need to be reduced; otherwise, you may get side effects.


Age restrictions 

Zyban is only suitable for adults aged 18 and over.


Pregnancy and breastfeeding

Don’t take Zyban if you are pregnant, think you may be pregnant or are planning to have a baby. If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, you must ask your doctor or Chemist4U pharmacist for advice before taking any new medicine. 



Some people find they are more sensitive to alcohol while taking Zyban. Your prescriber may suggest you do not drink alcohol while you’re taking Zyban, or try to drink as little as possible.


Driving and operating machinery 

Some of the side effects of Zyban, such as feeling dizzy or lightheaded, may affect your concentration and judgement. If you are affected, don’t drive or operate machinery.


Storage information

Store below 25°C in a cool, dry place out of sight and reach of children. Do not use after the expiry date, referring to the last day of the month stated on the packaging. Do not throw away any medicines via wastewater or household waste.


Important information

This product is a medicine; make sure to speak to your doctor or Chemist4U pharmacist before taking this product if you have an underlying medical problem or are taking any other medicine or complementary therapy. If your symptoms get worse or continue after taking this product, contact us or your doctor. For medical services in your area, please refer to https://www.nhs.uk

If you are pregnant, trying to become pregnant, or breastfeeding, speak to your doctor or Chemist4U pharmacist before taking this product. If you suffer from any allergies, ask your doctor or Chemist4U pharmacist if this medicine is right for you.

Store all medicines out of sight and reach of children.

Please read the included leaflet carefully before using this product.

Please contact your GP if appropriate regarding this product.

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