Diphenhydramine

Diphenhydramine is a drowsy antihistamine that can be used to treat temporary insomnia as well as coughs and colds.  Read More See less

It works by blocking the effect of histamine, a chemical in your brain that is released during an allergic reaction. This can reduce symptoms of cold and flu, as well as making you feel sleepy. 

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Frequently Asked Questions

Is diphenhydramine an antihistamine?

Yes, diphenhydramine is a type of drowsy antihistamine, but it’s not just used to treat allergies such as hay fever. It’s also used for short-term sleep problems, cough and cold symptoms, in addition to eczema, hives and insect bites and stings.


Does diphenhydramine have side effects?

Like all medicines, diphenhydramine may cause side effects in some people, but these won’t affect everybody. Side effects may include:


  • Drowsiness

  • Dry mouth

  • Dizziness

  • Trouble concentrating

Can I drink alcohol if I'm taking diphenhydramine?

It’s important that you don’t drink alcohol while you’re taking diphenhydramine. This is because the combination of alcohol and diphenhydramine can make you sleep very deeply. This may cause you not to be able to breathe properly and you may have difficulty waking up.

What is the usual diphenhydramine dosage for sleep?

If you’re taking diphenhydramine for short-term insomnia, your tablets will either be 25mg or 50mg in strength. You should take a tablet 20 minutes before you go to bed.

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